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Trisomy 18 is caused by the presence of an extra chromosome 18 47,xx+18 or 47,xy+18 in every cell of the body in 94% of cases. |
Predominance of females 4f1m clinical features growth retardation small mouth micrognathia small chin flat, pointed ears short neck clenched hands with overlapping fingers rockerbottom feet. |
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Trisomy 18 edwards syndrome karyotype 47,xx+18 or 47,xy+18 frequency 1 in 8,000 births. |
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